Fresh analysis suggests that patients who stop using new slimming jabs like semaglutide or tirzepatide can put back on lost weight at a significantly accelerated pace than those who halt conventional lifestyle regimens.
Published data in a leading health publication points out that while overweight individuals can lose substantial amounts of their total mass while on the medication, the weight comes back at an average rate of nearly a kilo each month once they quit.
"Users using these treatments should be cognizant of the potential of quick rebound weight gain when the therapy ends," stated lead investigator Dr. Susan Jebb.
That rate of recovery implies a return to starting weight within about a year and a half.
Weighing Approaches
The study, which reviewed dozens of studies involving thousands of patients, contrasted the outcomes of the injectable medications with conventional dieting.
Scientists emphasize that people who shed pounds through dieting usually see a more gradual weight regain—perhaps 0.1 kg a month—once they finish.
The Reason for the Quick Regain
Doctors believe the mode of action of the drugs is key to understanding the accelerated rebound.
These medications copy a body's own chemical called glucagon-like peptide-1, which controls hunger.
"Artificially providing the hormone levels far above than normal might result in the system to generate a reduced amount of its own natural GLP-1, and may also reduce responsiveness to its actions," noted Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this medication means hunger is unsuppressed, making binge eating a significant risk."
A Chronic Issue?
Health authorities advise the jabs for individuals with weight-linked health risks, accompanied by recommended diet and exercise modifications.
A number of clinicians argue that, considering the high risk of relapse, the therapy is often ongoing.
This perspective is echoed by drug manufacturers, who say that the results "underscore the long-term character of excess weight," comparing it to managing conditions like high blood pressure.
Patient Experiences
People who have discontinued the jabs report a sudden resurgence of appetite.
"It felt as if a trigger that goes on and you become ravenous," said one woman.
The struggle is compounded if individuals have not established sustainable lifestyle or habit changes during treatment.
Widespread Use
Survey data suggest that a significant number of adults in the UK have tried these injections in the past year, with interest remaining high.
- Adoption is greater among women than men.
- The 40s and 50s age group shows the greatest usage rates.
- Many obtain the medications through private prescriptions rather than public health services.
Ultimately, experts stress that while these medications are potent agents for weight loss, they are not a standalone fix and maintained weight loss hinges on integrated lifestyle support.
